Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing
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چکیده
منابع مشابه
Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing.
It remains an open question when and how the first cell fate decision is made in mammals. Using deep single-cell RNA-seq of matched sister blastomeres, we report highly reproducible inter-blastomere differences among 10 2-cell and five 4-cell mouse embryos. Inter-blastomere gene expression differences dominated between-embryo differences and noise, and were sufficient to cluster sister blastome...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2014
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.177725.114